Arrive in Santiago, vibrant capital of Chile, where you are met and transferred to your hotel nestled in the wine valley outside Santiago, with guaranteed check-in arranged by A&K. Enjoy time in the hotel’s beautiful gardens before gathering for an al fresco lunch in a tranquil setting. This afternoon, visit the Haras de Pirque vineyard and enjoy a wine tasting on site. Return to the hotel for a sunset cocktail and welcome dinner.

Set out on a full-day exploration of Valparaíso, starting with a guided walk along the hills of this storied port city. After lunch at a local restaurant, review the city’s fantastically colorful and inventive street art with a local expert guide. Then, take part in a brief interactive workshop that teaches you about South American murals and the unique techniques developed here to create them, and lets you try your hand at creating some street art of your own. Return to your hotel, where the rest of your evening is at leisure.

Take in the highlights of Santiago today, including a visit to the Pre-Columbian Museum to view its superb collections of statues, pottery and decor, with some pieces dating back 14,000 years. Then, fly to Mendoza, Argentina’s premier wine-making region, and settle into your hotel. Tonight, savor delicacies prepared by a renowned Argentine chef during an al fresco dining experience on the beautiful terrace of Restaurante 1884.

Journey to Las Carreras, a high-elevation plain abounding in rustic beauty, its yellow grasses contrasting with the white snow on the surrounding Andes peaks. Explore it with a guide on your choice of horseback riding or trekking. Watch for the wild species inhabiting the rugged landscapes, such as herds of guanacos and wild rabbits, and perhaps sight a condor gliding on the horizon. Afterward, proceed to Bellaviña, a private estate, for an exclusive, interactive Chef’s Table Experience followed by lunch. Learn more about one of the newest appellations (protected wine-producing areas) in Argentina. Planted by a husband-and-wife team and located at almost 7,500 feet, this appellation pushes the limits of high-altitude mountain viticulture. With breathtaking views of the mighty Andes and an intimate vineyard setting, Las Carreras offers a unique experience in Argentine wine tasting.

Today, begin at MAAL, a modern winery built entirely from recycled objects, from church pews to oak barrels. While here, learn the subtle art of winemaking by blending your own wine, a fun and educational activity. Start with three components — Merlot, Malbec and Cabernet — following instructions from a winemaker who explains what each of them brings to a blend. When you’re finished, enjoy a tasting and stay for lunch, served in the garden facing the majestic Andes. Afterward, fly to Buenos Aires and settle into your elegant luxury hotel, where you enjoy dinner tonight.

Take in some of the most compelling highlights of Buenos Aires, including the Plaza de Mayo, La Boca and San Telmo, as well as some of the vibrant, colorful graffiti art that adorns neighborhoods throughout the city. Break for lunch, and then enjoy an afternoon at leisure. This evening, transfer to Rojo Tango for dinner, followed by a captivating tango show that celebrates Argentina’s national dance.

This morning, board a flight to Iguazu, where you have lunch at the Melia Hotel, inside Iguazu National Park in Argentina. Then, set out to view the magnificent Iguazu Falls, traversing raised walkways and seeing the Devil’s Throat with your expert guide. Afterward, cross the border to Brazil on your way to the Hotel Das Cataratas, a Belmond Hotel and the only hotel located inside the Iguassu National Park in Brazil. This tropical rainforest is home to rare birds such as macaws, toucans and parrots, as well as monkeys, caimans, armadillos and even jaguars, so keep your eyes peeled. Check in to your hotel and enjoy the evening at your leisure.

Observe the mighty falls from two different vantage points, starting with a walking tour on the Brazilian side, taking in spectacular views and basking in a natural setting filled with orchids, colorful birds and endemic wildlife. Then, embark on a boat tour that takes you up close to the foot of the plummeting cascades for a visceral experience of the rainbow-making mists. Enjoy your afternoon at leisure. Tonight, gather for dinner at your hotel.

Today, fly to marvelous Rio de Janeiro, checking into your hotel upon arrival. This afternoon, tour iconic Sugar Loaf, ascending to the mountain’s upper reaches to take in panoramic vistas of the city and Guanabara Bay, and toasting the incredible view on a relaxing Scenic Sundowner experience. Tonight, enjoy a true Brazilian taste sensation with a dinner at Assador, a restaurant that takes barbecue to succulent new heights.

Explore downtown Rio de Janeiro on a guided walking tour in the historic city center, viewing sites central to local history and culture. Ride Like a Local along the way, hopping on and off the Rio VLT electric train, which also carries you to the revitalized port area to view the massive Cobra murals, each a dazzling example of Brazilian graffiti art. Then, get a taste of the city’s Carnival culture, enjoying insider access that takes you backstage to see the construction process of costumes and floats. Later this afternoon, travel to the heights of Corcovado Mountain for a spectacular glimpse of Rio. Also behold Corcovado’s crowning jewel, the majestic 120-foot-high statue of Christ the Redeemer — one of the Seven Wonders of the Modern World. Complete the evening with a special farewell dinner in the bohemian neighborhood of Santa Teresa, where you share stories and raise a toast to your amazing journey across South America.

Today, enjoy the opportunity to experience Rio de Janeiro your way, with one of these Design your Day activities.

• Visit a local NGO, supported by Abercrombie & Kent Philanthropy, that acts as an incubator and accelerator for a favela based ecosystem in the Vidigal favela.
• Bicycle Iconic Rio Neighborhoods: Copacabana, Ipanema, Leblon and the Rodrigo de Freitas Lagoon.
• Indulge in a Relaxing Massage with aromatic essential oils at your luxurious hotel’s spa.

Afterward, transfer to the airport for your departing flight.